--- a/setup.py
+++ b/setup.py
@@ -314,25 +314,25 @@
         lambda x: "third_party/boringssl" not in x, CORE_C_FILES
     )
     CORE_C_FILES = filter(lambda x: "src/boringssl" not in x, CORE_C_FILES)
-    SSL_INCLUDE = (os.path.join("/usr", "include", "openssl"),)
+    SSL_INCLUDE = (os.path.join("@TERMUX_PREFIX@", "include", "openssl"),)
 
 if BUILD_WITH_SYSTEM_ZLIB:
     CORE_C_FILES = filter(lambda x: "third_party/zlib" not in x, CORE_C_FILES)
-    ZLIB_INCLUDE = (os.path.join("/usr", "include"),)
+    ZLIB_INCLUDE = (os.path.join("@TERMUX_PREFIX@", "include"),)
 
 if BUILD_WITH_SYSTEM_CARES:
     CORE_C_FILES = filter(lambda x: "third_party/cares" not in x, CORE_C_FILES)
-    CARES_INCLUDE = (os.path.join("/usr", "include"),)
+    CARES_INCLUDE = (os.path.join("@TERMUX_PREFIX@", "include"),)
 
 if BUILD_WITH_SYSTEM_RE2:
     CORE_C_FILES = filter(lambda x: "third_party/re2" not in x, CORE_C_FILES)
-    RE2_INCLUDE = (os.path.join("/usr", "include", "re2"),)
+    RE2_INCLUDE = (os.path.join("@TERMUX_PREFIX@", "include", "re2"),)
 
 if BUILD_WITH_SYSTEM_ABSL:
     CORE_C_FILES = filter(
         lambda x: "third_party/abseil-cpp" not in x, CORE_C_FILES
     )
-    ABSL_INCLUDE = (os.path.join("/usr", "include"),)
+    ABSL_INCLUDE = (os.path.join("@TERMUX_PREFIX@", "include"),)
 
 EXTENSION_INCLUDE_DIRECTORIES = (
     (PYTHON_STEM,)
@@ -375,7 +375,7 @@
     EXTENSION_LIBRARIES += ("re2",)
 if BUILD_WITH_SYSTEM_ABSL:
     EXTENSION_LIBRARIES += tuple(
-        lib.stem[3:] for lib in pathlib.Path("/usr").glob("lib*/libabsl_*.so")
+        lib.stem[3:] for lib in pathlib.Path("@TERMUX_PREFIX@").glob("lib*/libabsl_*.so")
     )
 
 DEFINE_MACROS = (("_WIN32_WINNT", 0x600),)