--- a/Lib/aifc.py
+++ b/Lib/aifc.py
@@ -920,7 +920,7 @@
 if __name__ == '__main__':
     import sys
     if not sys.argv[1:]:
-        sys.argv.append('/usr/demos/data/audio/bach.aiff')
+        sys.argv.append('@TERMUX_PREFIX@/demos/data/audio/bach.aiff')
     fn = sys.argv[1]
     with open(fn, 'r') as f:
         print("Reading", fn)
--- a/Lib/mailcap.py
+++ b/Lib/mailcap.py
@@ -55,7 +55,8 @@
             # Don't bother with getpwuid()
             home = '.' # Last resort
         mailcaps = [home + '/.mailcap', '/etc/mailcap',
-                '/usr/etc/mailcap', '/usr/local/etc/mailcap']
+                '/usr/etc/mailcap', '/usr/local/etc/mailcap',
+                '@TERMUX_PREFIX@/etc/mailcap']
     return mailcaps
 
 
--- a/Lib/mimetypes.py
+++ b/Lib/mimetypes.py
@@ -49,6 +49,7 @@
     "/usr/local/lib/netscape/mime.types",
     "/usr/local/etc/httpd/conf/mime.types",     # Apache 1.2
     "/usr/local/etc/mime.types",                # Apache 1.3
+    "@TERMUX_PREFIX@/etc/mime.types",           # Termux
     ]
 
 inited = False
--- a/Lib/posixpath.py
+++ b/Lib/posixpath.py
@@ -32,7 +32,7 @@
 extsep = '.'
 sep = '/'
 pathsep = ':'
-defpath = '/bin:/usr/bin'
+defpath = '@TERMUX_PREFIX@/bin'
 altsep = None
 devnull = '/dev/null'
 
--- a/Lib/uuid.py
+++ b/Lib/uuid.py
@@ -361,7 +361,6 @@

     try:
         path_dirs = os.environ.get('PATH', os.defpath).split(os.pathsep)
-        path_dirs.extend(['/sbin', '/usr/sbin'])
         executable = shutil.which(command, path=os.pathsep.join(path_dirs))
         if executable is None:
             return None
--- a/Lib/subprocess.py
+++ b/Lib/subprocess.py
@@ -1389,9 +1389,7 @@
                 args = list(args)
 
             if shell:
-                # On Android the default shell is at '/system/bin/sh'.
-                unix_shell = ('/system/bin/sh' if
-                          hasattr(sys, 'getandroidapilevel') else '/bin/sh')
+                unix_shell = ('@TERMUX_PREFIX@/bin/sh')
                 args = [unix_shell, "-c"] + args
                 if executable:
                     args[0] = executable
--- a/Lib/tempfile.py
+++ b/Lib/tempfile.py
@@ -124,7 +124,7 @@
     if _os.name == 'nt':
         dirlist.extend([ r'c:\temp', r'c:\tmp', r'\temp', r'\tmp' ])
     else:
-        dirlist.extend([ '/tmp', '/var/tmp', '/usr/tmp' ])
+        dirlist.extend([ '@TERMUX_PREFIX@/tmp' ])
 
     # As a last resort, the current directory.
     try: